MLH3 Mutation in Endometrial Cancer

MLH3 mutation in endometrial cancer.

MLH3 is a recently described member of the DNA mismatch repair gene family. Based on its interaction with the MutL homologue MLH1, it was postulated that MLH3 might play a role in tumorigenesis. Germ line and somatic mutations in MLH3 have been identified in a small fraction of colorectal cancers, but the role of MLH3 in colorectal cancer tumorigenesis remains controversial. We investigated MLH...

Cancer risks after endometrial cancer in mismatch repair mutation carriers.

Recent years have seen increasing attention to the management of endometrial cancer risk in families with hereditary nonpolyposis colorectal cancer or Lynch syndrome (HNPCC/LS). Nevertheless, because endometrial cancer is less common and carries a lower mortality (1) than colorectal cancer in mismatch repair gene (MMR) mutation carriers, it may be an afterthought for many providers and patients...

Endometrial cancer

 کانسر آندومتر شایعترین بدخیمی دستگاه تناسلی زنان است، که تقریبا 7 درصد کانسرهای زنان را شامل می شود و چهارمین کانسر زنان بعد از کانسرهای (پستان، ریه و کلورکتال) در آمریکا است.

Prevalence of endometrial cancer in young patients

Background: Cancer of the endometrium is the most common gynecologic malignancy in western and industrial countries, and is the second most common in developing countries, therefore it is of special importance. Adenocarcinoma of the endometrium is the most common type of uterine cancer. The prevalence of endometrial cancer in young women under the age of 40 in western country is very low and ab...

Ovarian Metastasis in Endometriod Type Endometrial Cancer